This clinical study evaluated the effects of Ashwagandha root extract (ARE) on stress, sleep, cognition, and overall well-being in stressed adults. 130 participants were randomized to receive either Ashwagandha SR or placebo for 90 days. Results showed that Ashwagandha SR significantly improved cognitive function, including memory recall (CANTAB), reduced stress (lower PSS-10 score), decreased serum cortisol levels, and enhanced sleep quality (PSQI). Participants also reported better psychological well-being (OHQ score). Ashwagandha SR was safe, well-tolerated, and showed positive impacts on stress, cognition, and sleep.

Gopukumar et. al., 2021. Evid. Based Complement Alternat. Med. 2021 : doi:10.1155/2021/8254344

An eight-week, double-blind, placebo-controlled clinical trial demonstrated that supplementation with Ashwagandha significantly enhanced muscle strength, endurance, and muscle size in active adults. Specifically, improvements were observed in bench press and leg press strength, VO₂ max (a measure of aerobic capacity), and girth measurements of the arm, chest, and thigh. These benefits were evident in both men and women, with no adverse events reported.

Verma et. al., 2024. F1000Res. 12 : 335 doi: 10.12688/f1000research.130932.2

This randomized, double-blind, placebo-controlled clinical study evaluated the effect of a standardized Ashwagandha (Withania somnifera) root extract in healthy women experiencing low sexual desire. Women taking 300 mg of Ashwagandha twice daily for 8 weeks showed significant improvements in overall sexual function — including desire, arousal, lubrication, orgasm, satisfaction, and reduced discomfort — compared to placebo. They also reported fewer feelings of sexual distress and a higher frequency of satisfying sexual encounters. The extract was well-tolerated with no major safety concerns. These findings suggest that standardized Ashwagandha root extract can safely and effectively support female sexual wellness and function.

Ajgaonkar A. et al. Cureus. 2022;14(10):e30787. doi:10.7759/cureus.30787.

A clinical study on Withania somnifera evaluated its effects on semen quality, oxidative stress, and reproductive hormones in infertile men. Seventy-five infertile men and 75 healthy controls received supplementation, resulting in significant improvements in sperm count, motility, oxidative biomarkers and antioxidant vitamin levels (vitamins A, C, and E) in seminal plasma. The treatment also reduced oxidative stress and lipid peroxidation, while increasing serum testosterone (T) and luteinizing hormone (LH), and lowering levels of follicle-stimulating hormone (FSH) and prolactin (PRL). These findings suggest Withania somnifera effectively supports male reproductive health and hormone balance.

Ahmad et. al., 2010. Fertil. Steril. 94 : 989-996

This open-label, randomized, two-treatment, two-sequence, two-period, single-dose crossover clinical study compared the pharmacokinetics of Prolanza™ sustained-release Ashwagandha (Withania somnifera) root extract capsules (300 mg with 15 mg withanolides) against reference KSM-66 extract in 14 healthy men under fasting conditions, analyzing plasma levels of total withanolides, withanolide A, and 12-deoxywithastramonolide via LC-MS/MS. The test product demonstrated superior relative bioavailability (12x for total withanolides, 44x for withanolide A, 11x for 12-deoxywithastramonolide), longer half-life, and sustained-release properties, enabling longer-lasting effects from a single daily dose with no adverse events reported. This marks the first plasma quantification of key Ashwagandha phytoactives like withanolide A.

Alluri VKR et al. Int J Basic Clin Pharmacol. 2022 Jan;11(1):26-34